• Saltzman WM, Biomedical Engineering: Bridging Medicine and Technology, Second Edition, Cambridge University Press (2015).
  • Saltzman WM, Biomedical Engineering: Bridging Medicine and Technology, Cambridge University Press (2009).
  • Saltzman WM, Tissue Engineering: Principles for the design of replacement organs and tissues, Oxford University Press (2004).
  • Saltzman WM, Drug Delivery: Engineering principles for drug therapy, Oxford University Press (2001)


  • Baltazar T, Jiang B, Moncayo A, Merola J, Albanna MZ, Saltzman WM, and Pober JS. 3D bioprinting of an implantable xeno-free vascularized human skin graft, Bioengineering and Translational Medicine 8: e10324 (2023). PMCID: PMC9842062
  • Wang Y, Malik S, Suh HW, Xiao Y, Deng Y, Fan R, Huttner A, Bindra RS, Saltzman WM, and Bahal R. Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy. Science Advances 9:eabq7459 (2023). PMCID: PMC9908025.
  • Putman R, Ricciardi AS, Carufe KEW, Quijano E, Bahal R, Glazer PM, and Saltzman WM. Nanoparticle-mediated genome editing in single-cell embryos via peptide nucleic acids. Bioengineering and Translational Medicine 8:e10458 (2023). PMCID: PMC10189434.
  • Chang JS, Yu B, Saltzman WM, and Girardi M. Nanoparticles as a therapeutic delivery system for skin cancer prevention or treatment. JID Innovations 3:100197 (2023). PMCID: PMC10186617. 
  • Lee JH, Chapman DV, and Saltzman WM. Nanoparticle targeting with antibodies in the central nervous system, BME Frontiers, in press. 
  • Suberi A, Grun MK, Mao T, Israelow B, Reschke M, Grundler J, Akhtar L, Lee T, Shin K, Piotrowski-Daspit AS, Homer RJ, Iwasaki I, Suh HW, and Saltzman WM. Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination, Science Translational Medicine, in press. PMCID: PMC8963702
  • Chen AT, Xiao Y, Tang X, Baqri M, Gao X, Reschke M, Zhou Y, Deng G, Zhang S, Deng Y, Bai Z, Kim D, Huttner A, Kunes R, Saltzman WM, Fan R, Zhou J. Cross-platform analysis reveals cellular and molecular landscape of glioblastoma invasion, Neuro Oncology 25: 482-494 (2023). PMCID: in progress.
  • Ullrich SJ, Yung NK, Bauer-Pisani TJ, Maassel NL, Guerra ME, Freedman-Weiss M, Ahle SL, Ricciardi AS, Sauler M, Saltzman WM, Piotrowski-Daspit AS, and Stitelman DH. In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia. Molecular Therapy Nucleic Acids 32:594-602 (2023). PMCID: PMC10185702.
  • Richfield O, Shin K, Piotrowski-Daspit AS, Saltzman WM. Rational Nanoparticle Design: Optimization Using Insights from Experiments and Mathematical Models, Journal of Controlled Release, in press. PMCID: in progress. 


  • Beloor J, Kudalkar SN, Buzzelli G, Yang F, Mandl HK, Rajashekar JK, Spasov KA, Jorgensen WL, Saltzman WM, Anderson KS, and Kumar P. Long-acting and extended release antiretroviral implant and nanoformulations of a synergistic two-drug combination to treat and prevent HIV infection in humanized mice model, Bioengineering & Translational Medicine 7:e10237 (2022). PMCID: PMC8780078
  • Tiwari MK, Rios DC, Tumu H, Liu Y, Quijano E, Krysztofiak A, Chan C, Braddock DT, Suh HW, Saltzman WM, and Rogers FA. Direct targeting of amplified gene loci for pro-apoptotic anticancer therapy, Nature Biotechnology40:325-334 (2022). PMCID: PMC8930417
  • Reschke M, DiRito JR, Stern D, Day W, Piebanek N, Harris M, Hosgood SA, Nicholson ML, Pober JS, Saltzman WM, and Tietjen GT. A digital pathology tool for quantification of color features in histologic specimens, Bioengineering & Translational Medicine 7:e10242 (2022). PMCID: PMC8780932
  • Freedman-Weiss MR, Wu D, Maassel N, Ullrich SJ, Ahle SL, Roberts K, Farrelly JS, Buzzelli G, Saltzman WM, Stitelman DH. Engineering alginate microparticles for optimized accumulation in Fetal Rat Myelomeningocele, Journal of Pediatric Surgery 57:544-550. (2022) PMCID: in progress.
  • Vanderschuren K, Arranz-Gibert P, Khang M, Haar D, Gaudin A, Yang F, Folta-Stogniew E, Saltzman WM, Amiram M, Isaacs FJ. Tuning protein half-life in mouse using sequence-defined biopolymers functionalized with lipids. Proceedings of the National Academy of Sciences 119:e2103099119 (2022). PMCID: PMC8794819
  • Liu J, Wang X, Chen AT, Himes BT, Gao X, Zhang H, Chen Z, Wang J, Deng G, Xiao Y, Zou P, Zhang S, Liu F, Zhu Y, Fan R, Patel TR, Saltzman WM, and Zhou J. ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage, Nature Communications 13:2196 (2022). PMCID: PMC9033827
  • Luks V, Mandl H, DiRito J, Barone C, Freedman-Weiss MR, Ricciardi AS, Tietjen GG, Egan ME, Saltzman WM, and Stitelman D. Surface conjugation of antibodies improves nanoparticle uptake in bronchial epithelial Cells, PLOS ONE 17: e0266218 (2022). PMCID: PMC8986008
  • Piotrowski-Daspit AS, Barone C, Lin CY, Deng Y, Wu D, Ricciardi AS, Putman R, Gupta A, Fan R, Glazer PM, Saltzman WM, and Egan ME. In vivo correction of cystic fibrosis mediated by PNA nanoparticles, Science Advances8:eabo0522 (2022). PMCID: PMC9534507.
  • Albert C, Bracaglia L, Koide A, DiRito J, Lysyy T, Harkins L, Edwards C, Richfield O, Grundler J, Zhou K, Denbaum E, Ketavarapu G, HattoriT, Perincheri S, Langford J, Feizi A, Haakinson D, Hosgood SA, Nicholson ML, Pober JS, Saltzman WM, Koide S, Tietjen GT. Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications, Nature Communications 13:5998 (2022). PMCID: PMC9553936.
  • Khang M, Bindra RS, and Saltzman WM. Intrathecal delivery and its applications in leptomeningeal disease, Advanced Drug Delivery Reviews 186:114338 (2022).  PMCID: in progress. 
  • Mai Y, Ouyang Y, Yu M, Qin Y, Girardi M, Saltzman WM, Cocco E, Zhao C, Yu L, Jia Y, Xiao L, Dou L, Deng W, Liu Y, Xie J, and Deng Y. Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis, Journal of Controlled Release 349:354-366 (2022).
  • Shin K, Suh HW, Grundler J, Lynn AY, Pothupitiya JU, Moscato ZM, Bracaglia LG, Piotrowski-Daspit AS, and Saltzman WM. Polyglycerol and Poly(ethylene glycol) exhibit different effects on pharmacokinetics and antibody generation when grafted to nanoparticle surfaces, Biomaterials 287, 121676 (2022). PMCID: in progress.
  • Maassel NL, Wu DH, Yung NK, Bauer-Pisani T, Guerra ME, Ullrich SJ, Saltzman WM, Stitelman DH. Intra-amniotic injection of poly(lactic-co-glycolic acid) microparticles loaded with growth factor: Effect on tissue coverage and cellular apoptosis in the rat model of myelomeningocele, Journal of the American College of Surgeons 234(6):1010-1019 (2022).  PMCID: in progress.
  • Reschke M, Piotrowski-Daspit AS, Pober JS, and Saltzman WM. Nucleic acid delivery to the vascular endothelium, Molecular Pharmaceutics 19:4466-4486 (2022). PMCID: in progress
  • Mao T, Israelow B, Suberi A, Zhou L, Horwitz M, Peña-Hernández MA, Dong H, Homer RJ, Saltzman WM, Iwasaki A. Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses, Science 378:eabo2523 (2022). PMCID: PMC9798903.
  • Josowitz AD, Bindra RS, and Saltzman WM. Polymer nanocarriers for targeted local delivery of agents in treating brain tumors, Nanotechnology 34 DOI: PMCID: in progress
  • Pothupitiya JU, Zheng C, and Saltzman WM. Synthetic biodegradable polyesters for implantable controlled-release devices, Expert Opinion on Drug Delivery 19(10):1351-64 (2022). PMCID: in progress.   


  • DiRito JR, Hosgood SA, Reschke M, Albert C, Bracaglia LG, Ferdinand JR, Stewart BJ, Edwards CM, Vais AG, Thiru S, Mulligan DC, Haakinson DJ, Clatworthy MR, Saltzman WM, Pober JS, Nicholson ML, and Tietjen GT.  Ex vivo lysis of cold-storage-induced microvascular obstructions during normothermic perfusion of human kidney, American Journal of Transplantation 21:161-173 (2021).  PMCID: PMC7775334
  • Hu JK, Suh HW, Qureshi M, Lewis JM, Yaqoob S, Moscato ZM, Griff S, Lee AK, Yin ES, Saltzman WM, and Girardi M. Non-surgical treatment of skin cancer with local delivery of bioadhesive nanoparticles, Proceedings of the National Academy of Sciences 118: e2020575118 (2021). PMCID: PMC7896333
  • Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, and Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 6:e139067 (2021). PMCID: PMC8026182
  • Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell J, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JW, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J and the SCGE Consortium. The NIH Somatic Cell Genome Editing Consortium, Nature 592:195-204 (2021). PMCID: PMC8026397
  • Grun M, Suberi A, Shin K, Lee T, Gomerdinger V, Moscato ZM, Piotrowski-Daspit AS, and Saltzman WM. PEGylation of Poly(amine-co-ester) Polyplexes for Versatile Delivery of Nucleic Acids In Vitro and In Vivo, Biomaterials 272:120780 (2021). PMCID: PMC8085770
  • Ullrich SJ*, Freedman-Weiss M*, Ahle S, Mandl HK, Piotrowski-Daspit AS, Roberts K, Yung N, Maassel N, Bauer-Pisani T, Ricciardi AS, Egan ME, Glazer PM, Saltzman WM, and Stitelman DH. Nanoparticles for delivery of agents to fetal lung, Acta Biomaterialia 123: 346-353 (2021). PMCID: PMC7962939
  • Wang Y, Jiang Y, Wei D, Singh P, Yu Y, Lee T, Zhang L, Mandl H, Piotrowski-Daspit A, Chen X, Li F, Li X, Cheng Y, Josowitz A, Yang F, Zhao Y, Wang F, Zhao Z, Huttner A, Bindra RS, Xiao H, and Saltzman WM, Reduction-responsive nanoformulations overcome temozolomide-resistance in glioblastoma, Nature Biomedical Engineering, 5, 1048–1058 (2021). PMCID: PMC8497438
  • Xu E, Piotrowski-Daspit AS, and Saltzman WM. Escaping the endosome: assessing cellular trafficking mechanisms of non-viral vehicles, Journal of Controlled Release 335:465-480 (2021). PMCID: in progress
  • Malik S, Saltzman WM, and Bahal R. Extracellular vesicles mediated exocytosis of antisense peptide nucleic acids, Molecular Therapy - Nucleic Acids 25:302-315 (2021). PMCID: PMC8379631
  • Grundler J, Shin K, Suh HW, Zhong M, and Saltzman WM. Surface topography of poly(ethylene glycol) shell nanoparticles formed from bottlebrush polymers controls interactions with proteins and cells, ACS Nano 15:16118-16129 (2021). PMCID: PMC8919421


  • Baltazar T, Merola J, Catarino C, Xie CB, Kirkiles-Smith NC, Lee V, Hotta S, Dai G, Xu X, Ferreira FC, Saltzman WM, Pober JS, Karande P. 3D bioprinting of a vascularized and perfusable skin graft using human keratinocytes, fibroblasts, pericytes and endothelial cells, Tissue Engineering, 26(5-6):227-238 (2020). PMCID: PMC7476394 
  • Lysyy T, Bracaglia LG, Qin L, Albert C, Pober JS, Tellides G, Saltzman WM, and Tietjen GT. Ex vivo isolated human vessel perfusion system for assessment of vascular-targeted nanomedicines, Bioengineering & Translational Medicine, 5(2): e10154 (2020). PMCID: PMC7237142.
  • Oyaghire SN, Quijano E, Piotrowski-Daspit AS, Saltzman WM, and Glazer PM. Poly(lactic-co-glycolic acid) Nanoparticle Delivery of Peptide Nucleic Acids In Vivo. Methods Mol Biol 2105:261-281 (2020). PMCID: PMC7199467  
  • Bracaglia LG, Piotrowski-Daspit AS, Lin CY, Moscato ZM, Wang Y, Tietjen GT, and Saltzman WM. Quantitative, High-throughput half-life measurements of intravenously injected agents in vivo, Proceedings of the National Academy of Sciences 117:3502-3508 (2020). PMCID: PMC7035491
  • Jiang Y, Lu Q, Wang Y, Xu E, Ho A, Singh P, Wang Y, Tietjen GT, Cresswell P, and Saltzman WM. Quantitative analysis of endosomal escape using a library of polymers for mRNA delivery. Nano Letters 20:1117-1123 (2020). PMCID: PMC7195212
  • Economos NG, Oyaghire S, Quijano E, Ricciardi A, Saltzman WM, and Glazer PM. Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair, Molecules 25:735 (2020).  PMCID: PMC7037966 
  • Piotrowski-Daspit AS, Kauffman AC, Bracaglia LG, and Saltzman WM. Polymeric vehicles for nucleic acid delivery, Advanced Drug Delivery Reviews 156:119-132 (2020). PMCID: PMC7736472


  • Suh H-W, Lewis J, Fong L, Ramseier JY, Carlson K, Peng Z, Yin ES, Saltzman WM, and Girardi M. Biodegradable bioadhesive nanoparticle incorporation of  broad-spectrum organic sunscreen agents. Bioengineering & Translational Medicine, 4:129-140 (2019). PMCID: PMC6336670.
  • Martin DT, Shen H, Steinbach-Rankins JM, Zhu X, Johnson KK, Syed J, Saltzman WM, and Weiss RM. Glycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target. Molecular Cancer Therapeutics 18: 413-420 (2019).  PMCID: PMC6363894
  • Baro M, Lopez Sambrooks C, Quijano AR, Saltzman WM, and Contessa J. Oligosaccharyltransferase inhibition reduces receptor tyrosine kinase activation and enhances glioma radiosensitivity, Clinical Cancer Research 25:784-795 (2019). PMCID: PMC6314911
  • Farrelly JS, Bianchi AH, Ricciardi AS, Buzzelli G, Ahle SL, Freedman-Weiss MR, Luks VL, Saltzman WM, and Stitelman DH. Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele, Journal of Pediatric Surgery 54: 80-85 (2019).
  • Seo Y, Suh H, Bahal R, Josowitz A, Song E, Zhang J, Cui J, Noorbakhsh S, Jackson C, Bu T, Bindra R, Saltzman WM. Nanoparticle-mediated intratumoral inhibition of miR-21 for improved survival in glioblastoma, Biomaterials 201: 87-98 (2019).  PMCID: PMC6451656
  • Siefert AL, Cartiera MS, Khalid AN, Nantel MC, Loose CR, Schulam PG, Saltzman WM, and Dempsey MK.  The Yale Center for Biomedical Innovation and Technology (CBIT): One model to accelerate impact from academic health care innovation, Academic Medicine 94:528-534 (2019).
  • Cui J, Piotrowski-Daspit AS, Zhang J, Shao M, Bracaglia LG, Utsumi T, Seo YE, DiRito J, Song E, Wu C, Inada A, Tietjen G, Pober JS, Iwakiri Y, and Saltzman WM. Poly(amine-co-ester) nanoparticles for effective Nogo-B knockdown in the liver, Journal of Controlled Release 304:259-267 (2019). PMCID: PMC6613984
  • Kudalkara SN, Ullahc I, Bertolettia N, Mandl HK, Cisnerose JA, Beloorc J, Chana AH, Saltzman WM, Jorgensen WL, Kumar P, and Anderson KS. Structural and Pharmacological Evaluation of a Novel Non-nucleoside Reverse Transcriptase Inhibitor as a Promising Long Acting Nanoformulation for Treating HIV, Antiviral Research,167:110-116 (2019). PMCID: PMC6554724
  • Kural MH, Wang J, Gui L, Li G, Yuan Y, Leiby K, Quijano E, Tellides G, Saltzman WM, and Niklason LE. Fas ligand and nitric oxide combination to control smooth muscle growth while sparing endothelium. Biomaterials 212:28-38 (2019). PMCID: PMC6567994
  • Merola J, Reschke M, Pierce RW, Qin L, Spindler S, Baltazar T, Manes TD, Lopez F, Li G, Bracaglia L, Xie C, Kirkiles-Smith N, Saltzman WM, Tietjen GT, Tellides G, Pober JS. Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression, JCI Insight 4(20):e129739 (2019). PMCID: PMC6824302
  • Mandl HK, Quijano E, Suh HW, Sparago E, Grun M, Glazer PM, and Saltzman WM. Optimizing biodegradable nanoparticle size for tissue-specific delivery, Journal of Controlled Release 314:92-101 (2019). PMCID: PMC6909251


  • Kauffman AC, Piotrowski-Daspit AS, Nakazawa KH, Jiang Y, Datye A, Saltzman WM. Tunability of Biodegradable Poly(amine-co-ester) Polymers for Customized Nucleic Acid Delivery and Other Biomedical Applications. Biomacromolecules. 2018 Aug 15. doi: 10.1021/acs.biomac.8b00997. [Epub ahead of print] 
  • Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS. Reply to Pandey et al.: Understanding the efficacy of a potential antiretroviral drug candidate in humanized mouse model of HIV infection. Proc Natl Acad Sci U S A. 2018 Aug 10. pii: 201810136. doi:10.1073/pnas.1810136115. [Epub ahead of print].
  • Lopez Sambrooks C, Baro M, Quijano A, Narayan A, Wei C, Greninger P, Egan RK, Patel AA, Benes CH, Saltzman WM, Contessa JN. Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors. Cancer Res. 2018 Jul 19. pii: canres.0505.2018. doi: 10.1158/0008-5472.CAN-18-0505. [Epub ahead of print] 
  • Baro M, Lopez Sambrooks C, Quijano A, Saltzman WM, Contessa JN. Oligosaccharyltransferase inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity. Clin Cancer Res. 2018 Jul 2. pii: clincanres.0792.2018. doi: 10.1158/1078-0432.CCR-18-0792. [Epub ahead of print] 
  •  Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R,  López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. In utero nanoparticle delivery for site-specific genome editing. Nat Commun. 2018 Jun 26;9(1):2481. doi: 10.1038/s41467-018-04894-2. 
  • Chen EM, Quijano AR, Seo YE, Jackson C, Josowitz AD, Noorbakhsh S, Merlettini  A, Sundaram RK, Focarete ML, Jiang Z, Bindra RS, Saltzman WM. Biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors. Biomaterials. 2018 Jun 18;178:193-203. doi: 10.1016/j.biomaterials.2018.06.024. [Epub ahead of print] 
  • Tietjen GT, Bracaglia LG, Saltzman WM, Pober JS. Focus on Fundamentals:
    Achieving Effective Nanoparticle Targeting. Trends Mol Med. 2018 Jun 5. pii:
    S1471-4914(18)30100-X. doi: 10.1016/j.molmed.2018.05.003. [Epub ahead of print]
  • Jiang Y, Gaudin A, Zhang J, Agarwal T, Song E, Kauffman AC, Tietjen GT, Wang Y, Jiang Z, Cheng CJ, Saltzman WM. A “top-down” approach to actuate poly(amine-co-ester) terpolymers for potent and safe mRNA delivery. Biomaterials. 2018 Sep;176:122-130. doi: 10.1016/j.biomaterials.2018.05.043. Epub 2018 May 25. 
  • Ricciardi AS, Quijano E, Putman R, Saltzman WM, Glazer PM. Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing. Molecules. 2018 Mar 11;23(3).pii: E632. doi: 10.3390/molecules23030632. Review.
  • Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM,Kumar P, Jorgensen WL, Anderson KS. From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection. Proc Natl Acad Sci U S A. 2018Jan 23;115(4):E802-E811. doi: 10.1073/pnas.1717932115. Epub 2017 Dec 26. Erratum in: Proc Natl Acad Sci U S A. 2018 Mar 12;:. 


  • Seo YE, Bu T, Saltzman WM. Nanomaterials for convection-enhanced delivery of agents to treat brain tumors. Curr Opin Biomed Eng. 2017 Dec;4:1-12. doi:10.1016/j.cobme.2017.09.002. Epub 2017 Sep 22. PubMed PMID: 29333521; PubMedCentral PMCID: PMC5761746.
  • Quijano E, Bahal R, Ricciardi A, Saltzman WM, Glazer PM. Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities. Yale J Biol Med. 2017 Dec 19;90(4):583-598. eCollection 2017 Dec. Review. PubMed PMID: 29259523; PubMed Central PMCID: PMC5733847.
  • Gupta A, Quijano E, Liu Y, Bahal R, Scanlon SE, Song E, Hsieh WC, Braddock DE,Ly DH, Saltzman WM, Glazer PM. Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy. Mol Ther Nucleic Acids. 2017 Dec15;9:111-119. doi: 10.1016/j.omtn.2017.09.001. Epub 2017 Sep 12. PubMed PMID:29246289; PubMed Central PMCID: PMC5633812.
  • Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D, Song E, Kraehling JR,Piotrowski-Daspit AS, Kirkiles-Smith NC, Al-Lamki R, Thiru S, Bradley JA,Saeb-Parsy K, Bradley JR, Nicholson ML, Saltzman WM, Pober JS. Nanoparticletargeting to the endothelium during normothermic machine perfusion of human kidneys. Sci Transl Med. 2017 Nov 29;9(418). pii: eaam6764. doi:10.1126/scitranslmed.aam6764. PubMed PMID: 29187644.
  • Chi DL, Song E, Gaudin A, Saltzman WM. Improved threshold selection for the determination of volume of distribution of nanoparticles administered by convection-enhanced delivery. Comput Med Imaging Graph. 2017 Dec;62:34-40. doi:10.1016/j.compmedimag.2017.08.001. Epub 2017 Aug 24. PubMed PMID: 28927549;PubMed Central PMCID: PMC5716935.
  • Mohideen M, Quijano E, Song E, Deng Y, Panse G, Zhang W, Clark MR, Saltzman WM. Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir. Biomaterials. 2017 Nov;144:144-154. doi:10.1016/j.biomaterials.2017.08.029. Epub 2017 Aug 15. PubMed PMID: 28829952;PubMed Central PMCID: PMC5581224.
  • King AR, Corso CD, Chen EM, Song E, Bongiorni P, Chen Z, Sundaram RK, Bindra
    RS, Saltzman WM. Local DNA repair inhibition for sustained radiosensitization in
    high grade gliomas. Mol Cancer Ther. 2017 May 31. pii: molcanther.0788.2016. doi:
    10.1158/1535-7163.MCT-16-0788. [Epub ahead of print] PubMed PMID: 28566437.
  • Song E, Gaudin A, King AR, Seo YE, Suh HW, Deng Y, Cui J, Tietjen GT, Huttner
    A, Saltzman WM. Surface chemistry governs cellular tropism of nanoparticles in
    the brain. Nat Commun. 2017 May 19;8:15322. doi: 10.1038/ncomms15322. PubMed
    PMID: 28524852; PubMed Central PMCID: PMC5454541.
  • Tietjen GT, DiRito J, Pober JS, Saltzman WM. Quantitative microscopy-based
    measurements of circulating nanoparticle concentration using microliter blood
    volumes. Nanomedicine. 2017 Apr 13;13(6):1863-1867. doi:
    10.1016/j.nano.2017.04.003. [Epub ahead of print] PubMed PMID: 28412144.
  • Cocco E, Deng Y, Shapiro EM, Bortolomai I, Lopez S, Lin K, Bellone S, Cui J,
    Menderes G, Black JD, Schwab CL, Bonazzoli E, Yang F, Predolini F, Zammataro L,
    Altwerger G, de Haydu C, Clark M, Alvarenga J, Ratner E, Azodi M, Silasi DA,
    Schwartz PE, Litkouhi B, Saltzman WM, Santin AD. Dual-Targeting Nanoparticles for
    In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells.
    Mol Cancer Ther. 2017 Feb;16(2):323-333. doi: 10.1158/1535-7163.MCT-16-0501. Epub
    2016 Dec 12. PubMed PMID: 27956521; PubMed Central PMCID: PMC5292071.


  • Deng Y, Yang F, Cocco E, Song E, Zhang J, Cui J, Mohideen M, Bellone S, Santin
    AD, Saltzman WM. Improved i.p. drug delivery with bioadhesive nanoparticles. Proc
    Natl Acad Sci U S A. 2016 Oct 11;113(41):11453-11458. PubMed PMID: 27663731.
  • Gaudin A, Song E, King AR, Saucier-Sawyer JK, Bindra R, Desmaële D, Couvreur P, Saltzman WM. PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma. Biomaterials. 2016 Oct;105:136-44. doi:10.1016/j.biomaterials.2016.07.037. Epub 2016 Aug 4. PubMed PMID: 27521616.
  • Belinsky GS, Sreekumar B, Andrejecsk JW, Saltzman WM, Gong J, Herzog RI, Lin S, Horsley V, Carpenter TO, Chung C. Pigment epithelium-derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade. FASEB J. 2016 Aug;30(8):2837-48. doi: 10.1096/fj.201500027R. Epub 2016 Apr 28. PubMed PMID:27127101; PubMed Central PMCID: PMC4970601.
  • Saucier-Sawyer JK, Seo YE, Gaudin A, Quijano E, Song E, Sawyer AJ, Deng Y, Huttner A, Saltzman WM. Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors. J Control Release. 2016 Jun 28;232:103-12. doi: 10.1016/j.jconrel.2016.04.006. Epub 2016 Apr 8. PubMed PMID: 27063424; PubMed Central PMCID: PMC4893898.
  • Moore LB, Sawyer AJ, Saucier-Sawyer J, Saltzman WM, Kyriakides TR. Nanoparticle delivery of miR-223 to attenuate macrophage fusion. Biomaterials. 2016 May;89:127-35. doi: 10.1016/j.biomaterials.2016.02.036. Epub 2016 Feb 26.PubMed PMID: 26967647; PubMed Central PMCID: PMC4924476.
  • Park JK, Utsumi T, Seo YE, Deng Y, Satoh A, Saltzman WM, Iwakiri Y. Cellular distribution of injected PLGA-nanoparticles in the liver. Nanomedicine. 2016 Jul;12(5):1365-74. doi: 10.1016/j.nano.2016.01.013. Epub 2016 Mar 4. PubMed PMID: 26961463; PubMed Central PMCID: PMC4889500.
  • Abrahimi P, Qin L, Chang WG, Bothwell AL, Tellides G, Saltzman WM, Pober JS. Blocking MHC class II on human endothelium mitigates acute rejection. JCI Insight. 2016;1(1). pii: e85293. Epub 2016 Jan 21. PubMed PMID: 26900601; PubMed  Central PMCID: PMC4756651.
  • Gupta A, Bahal R, Gupta M, Glazer PM, Saltzman WM. Nanotechnology for delivery of peptide nucleic acids (PNAs). J Control Release. 2016 Jan 8. pii: S0168-3659(16)30004-9. doi: 10.1016/j.jconrel.2016.01.005. [Epub ahead of print]  PubMed PMID: 26776051; PubMed Central PMCID: PMC5016210.


  • Saucier-Sawyer JK, Deng Y, Seo YE, Cheng CJ, Zhang J, Quijano E, and Saltzman WM. Systemic delivery of blood-brain barrier targeted polymeric nanoparticles enhances delivery to brain tissue, Journal of Drug Targeting 23:736-749 (2015).  [PCMID: in process]
  • Gavrilov K, Seo YE, Tietjen GT, Cui J, Cheng CJ, and Saltzman WM. Enhancement in siRNA potency by optimization outside of target sequence selection, Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1517039112 E6597-E6605 (2015). [PCMID: in process]
  • Adams BD, Wali VB, Cheng CJ, Inukai S, Hu J, Booth C, Rimm DL, Győrffy B, Pusztai L, Saltzman WM, and Slack FJ. miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple Negative Breast Cancer, Cancer Research, in press. [PCMID: in process]
  • Steinbach JM, Seo Y, and Saltzman WM. CPP-Modified PLGA Nanoparticles for Enhanced Cell Internalization, Acta Biomaterialia, in press. [PCMID: in process]
  • Chang WG, Fornoni A, Mendez JJ, Niklason LE, Saltzman WM, and Pober JS, Tissue engineered microvasculature to re-perfuse isolated renal glomeruli, Tissue Engineering Part A 21:2673-2679 (2015). 
  • Deng Y, Ediriwickrema A, Yang F, Lewis J, Girardi M, Saltzman WM. A sunblock based on bioadhesive nanoparticles. Nat Mater. 2015 Dec;14(12):1278-85. doi:10.1038/nmat4422. Epub 2015 Sep 28. PubMed PMID: 26413985; PubMed Central PMCID:PMC4654636.
  • Tietjen GT and Saltzman WM. Nanomedicine gets personal [Commentary], Science Translational Medicine, 7, 314fs47 (2015).
  • Cocco E, Shapiro E, Gasparrini S, Lopez S, Schwab S, Bellone S, Bortolamai I, Sumi NJ, Bonnazzoli E, Nicoletti R, Deng Y, Saltzman WM, Zeiss CJ, Centritto F, Silasi DA, Ratner E, Azodi M, Rutherford TJ, Schwartz PE, Pecorelli S, and Santin AD. Clostridium Perfringens Enterotoxin C-terminal fragment conjugated to fluorescent dyes for in vivo visualization of metastatic chemotherapy-resistant ovarian cancer, International Journal of Cancer, in press.
  • Andrejecsk JW, Chang WG, Pober JS, and Saltzman WM. Controlled protein delivery in the generation of microvascular networks, Drug Delivery and Translational Research 5: 75-88 (2015). PMCID: PMC4354697
  • Fields RJ, Quijano E, McNeer NA, Caputo C, Bahal R, Anandalingam K, Egan ME, Glazer PM, Saltzman WM. Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung, Advanced Healthcare Materials 18: 361-366 (2015) PMCID:PMC4339402.
  • Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, and Slack FJ. MicroRNA silencing for cancer therapy targeted to the tumor microenvironment, Nature 518:107-110 (2015). PMCID: PMC4367962.
  • Strohbehn G, Coman D, Han L, Ragheb RT, Fahmy TM, Huttner AJ, Hyder F, Piepmeier JM, Saltzman WM, and Zhou J. Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance, Journal of Neuro-Oncology 121:441-449 (2015). PMCID: PMC4323763.
  • Cheng CJ, Tietjen GT, Saucier-Sawyer JK, and Saltzman WM. A holistic approach to targeting disease with polymer nanoparticles, Nature Reviews Drug Discovery 14:239-247 (2015). [PMCID: in process].
  • McNeer NA, Anandalingam K, Quijano E, Fields RJ, Caputo C, Glazer PM, Saltzman WM, and Egan ME. In vivo and in vitro correction of F508del CFTR using nanoparticles with triplex-forming PNAs in airway epithelia. Nature Communications 6:6952 (2015). [PMCID: in process].
  • Ediriwickrema A and Saltzman WM. Nanotherapy for Cancer: Targeting and multi-functionality in the future of cancer therapies. ACS Biomaterials Science & Engineering 1:64-78 (2015). PCMID: PMC4426346.
  • Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, and Pober JS. Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9, Circulation Research, 117: 121-128 (2015). [PCMID: in process].


  • Sirianni RW, Zheng MQ, Patel TR, Shafbauer T, Zhou J, Saltzman WM, Carson RE, and Huang Y. Radiolabeling of poly(lactic acid-co-glycolic acid (PLGA) nanoparticles with biotinylated F-18 prosthetic group and imaging of their delivery to the brian with positron emission tomography, Bioconjugate Chemistry, 25:2157-2165 (2014). PMCID: PMC4275164. 
  • Fields RJ, Quijano E, McNeer NA, Caputo C, Bahal R, Anandalingam K, Egan ME, Glazer PM, Saltzman WM. Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung, Advanced Healthcare Materials, in press. 
  • Ediriwickrema A, Zhou J, Deng Y, and Saltzman WM. Multi-layer nanoparticles for combinatorial gene and drug delivery to tumors, Biomaterials 35:9343-9354 (2014). 
  • Bahal R, Quijano E, McNeer NA, Liu Y, Bhunia DC, López F, Saltzman WM, Ly DH, Glazer PM. Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition, Current Gene Therapy, 14:331-342 (2014). 
  • Gupta R, Dong Y, Solomon PD, Wettersten HI, Cheng CJ, Min JN, Henson J, Dogra SK, Hwang SH, Hammock BD, Zhu LJ, Reddel RR, Saltzman WM, Weiss RH, Chang S, Green MR, Wajapeyee N, Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A, Proceedings of the National Academy of Sciences 111 (30): E3062-E3071 (2014). 
  • Weiser JR and Saltzman WM. Controlled release for local delivery of drugs: Barriers, models, and opportunities, Journal of Controlled Release 190:664-673 (2014). 
  • Ricciardi AS, McNeer NA, Anandalingam K, Saltzman WM, and Glazer PM. Tar-geted genome modification via triple helix formation, Methods in Molecular Biology 1176:89-106 (2014). 
  • Sawyer AJ, Tian W, Saucier-Sawyer JK, Rizk PJ, Saltzman WM, Bellamkonda RV, Kyriakides TR. The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic inflammation, Biomaterials 35:6698-6706 (2014). 
  • Deng Y, Saucier-Sawyer JK, Hoimes CJ, Zhang J, Seo YE, Andrejecsk JW, and Saltzman WM. The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles. Biomaterials 35:6595-6602 (2014). 
  • Gattu A, Birkenfeld A, Iwakiri Y, Jay SM, Saltzman WM, Doll J, Protiva P, Jornyvaz F, Samuel V, Crawford SE, and Chung C. Pigment Epithelium-Derived Factor (PEDF) suppresses IL-1beta-mediated c-Jun N-terminal Kinase (JNK) activation to improve hepatocyte insulin signaling, Endocrinology 155:1373-85 (2014). 
  • Martin DT, Steinbach JM, Liu J, Shimizu S, Kaimakliotis HZ, Wheeler MA, Hittelman AB, Saltzman WM, Weiss RM. Surface modified nanoparticles enhance transurothelial penetration and delivery of survivin siRNA in treating bladder cancer, Molecular Cancer Therapeutics 13:71-81 (2014). 
  • Devalliere J, Chang WG, Andrejecsk JW, Cheng CJ, Jane-wit D, Saltzman WM, and Pober JS. Sustained delivery of pro-angiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation, FASEB Journal 28(2): 908-922 (2014). 
  • Look M, Saltzman WM, Craft J, and Fahmy TM. Nanomaterial-dependent modulation of dendritic cells affects the extent of therapeutic immunosuppresion in lupus, Biomaterials 35:1089-1095 (2014). 
  • Saltzman WM and Kyriakides TR. Cell interactions with polymers In Principles of Tissue Engineering, Fourth edition, RP Lanza, R Langer, J Vacanti (Ed.), Academic Press, NY, p. 385-406 (2014). 

   2013                                                                                                                                      Back to top

  • Kobsa S, Kristofik NJ, Sawyer AJ, Bothwell A, Kyriakides TR, and Saltzman WM. An electrospun scaffold integrating nucleic acid delivery for treatment of full thickness wounds, Biomaterials 34:3891-3901 (2013). 
  • Du X, Li W, Gao X, Saltzman WM, Cheng CJ, Stewart C, Zheng J, and Kopke RD. Regeneration of mammalian cochlear and vestibular hair cells through Hes1/ Hes5 modulation with siRNA, Hearing Research 304:91-110 (2013). 
  • Zhou J, Patel TR, Sirianni RW, Strohbehn G, Zheng MQ, Duong N, Schafbauer T, Huttner AJ, Huang Y, Carson RE, Zhang Y, Sullivan DJ, Piepmeier JM, and Saltzman WM. Highly penetrative nanocarriers loaded with drugs targeted to resistant cells improve treatment of glioblastoma, Proceedings of the National Academy of Sciences, 110 (29): 11751-11756 (2013). 
  • Sirianni RW, Zheng MQ, Saltzman WM, Huang Y, and Carson RE. Direct, quanti-tative, and non-invasive imaging of the transport of active agents through intact brain with Positron Emission Tomography, Molecular Imaging & Biol-ogy,15:596-605 (2013). 
  • Martin DT, Hoimes CJ, Kaimakliotis HZ, Zhang K, Cheng CJ, Liu J, Wheeler MA, Kelly KW, Tew GN, Saltzman WM, and Weiss RM. Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer, Nanomedicine 9:1124-1134 (2013). 
  • Bahal R, McNeer NA, Ly DH, Saltzman WM, and Glazer PM. Nanoparticles for delivery of antisense γPNA oligomers targeting CCR5, Artificial DNA: PNA & XNA 4:49-57 (2013). 
  • Andrejecsk JW, Cui J, Chang WG, Devalliere J, Pober JS, Saltzman WM. Paracrine exchanges of molecular signals between alginate-encapsulated peri-cytes and freely suspended endothelial cells within a 3D protein gel, Biomaterials 35(5):8899-8908 (2013). 
  • Cheng CJ, Saltzman WM, Slack FJ. Canonical and non-canonical barriers facing antimiR cancer therapeutics. Curr Med Chem 20:3582-3593 (2013). 
  • Chang WG, Andrejecsk JW, Kluger MS, Saltzman WM, and Pober JS. Pericytes modulate endothelial sprouting. Cardiovascular Research 100:492-500 (2013). 
  • Schleifman EB, McNeer NA, Jackson A, Yamtich J, Leif J, Shultz LD, Greiner DL, Kumar P, Saltzman WM, and Glazer PM. Site-specific genome editing in PBMCs with PLGA nanoparticle-delivered PNAs confers HIV-1 resistance in humanized mice, Molecular Therapy-Nucleic Acids, Nov 19;2:e135. doi: 10.1038/mtna.2013.59 (2013). 
  • Zhang J and Saltzman WM. Engineering Biodegradable Nanoparticles for Drug and Gene Delivery. Chemical Engineering Progress. March:25-30 (2013). 

   2012                                                                                                                                Back to top

  • Zhou J, Patel T, Fu M, Bertram JB, and Saltzman WM. Octa-functional PLGA nanoparticles for targeted and efficient siRNA delivery to tumors, Biomaterials 33:583-591 (2012). 
  • Zhou J, Liu J, Cheng CJ, Patel T, Weller C, Piepmeier JM, Jiang Z, and Saltzman WM. Biodegradable poly(amine-co-ester) terpolymers for targeted gene deliv-ery, Nature Materials 11:82-90 (2012).  
  • Gavrilov K and Saltzman WM. Therapeutic siRNA: principles, challenges, and strategies. Yale J Biol Med 85: 187-200 (2012).  
  • Fields R, Cheng CJ, Quijano E, Weller C, Kristofik N, Duong N, Hoimes C, Egan ME, Saltzman WM Surface modified poly(β amino ester)-containing nanoparti-cles for plasmid DNA delivery, Journal of Controlled Release 164:41-48 (2012).  
  • McNeer NA, Schleifman EB, Cuthbert A, Brehm M, Jackson A, Cheng C, Anandal-ingam K, Kumar P, Shultz LD, Greinert DL, Saltzman WM, and Glazer PM. Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles me-diates site-specific genome editing of human hematopoietic cells in vivo, Gene Therapy, 20:658-669 (2012).
  • Qian, L, Krause DS, and Saltzman WM. Enhanced growth and hepatic differentiation of fetal liver epithelial cells through combinatorial and temporal adjustment of soluble factors, Biotechnology Journal 7:440-448 (2012). 
  • Patel T, Zhou J, Piepmeier JM, and Saltzman WM. Polymeric nanoparticles for drug delivery to the central nervous system. Advanced Drug Delivery Reviews 64:701-705 (2012). 
  • Zhou J, Atsina K-B, Himes B, Strohbehn G, Saltzman WM. Novel delivery strategies for glioblastoma. The Cancer Journal, 18:89-99 (2012). 
  • Cheng CJ and Saltzman WM. Polymer nanoparticle-mediated delivery of microRNA inhibition and alternative splicing. Molecular Pharmaceutics 9:1481-1488 (2012). 
  • Steinbach JM, Weller CE, Booth CJ, and Saltzman WM. Polymer nanoparticles with siRNA for treatment of HSV-2 genital infection, Journal of Controlled Release 162:102-110 (2012). 
  • Babar IA, Cheng CJ, Booth CJ, Liang X, Weidhaas JB, Saltzman WM, Slack FJ. Nanoparticle-based therapy in an in vivo miR-155-dependent mouse model of lymphoma, Proceedings of the National Academy of Sciences 109 (26) E1695-E1704 (2012). 
  • Andrejecsk JW, Chang WG, Pober JS, and Saltzman WM. Controlled protein de-livery in the generation of microvascular networks, Drug Delivery and Transla-tional Research, DOI 10.1007/s13346-012-0122-y (2012).  
  • Cheng CJ and Saltzman WM. Down-sizing tumour therapeutics. Nature Nanotechnology 7:346-347 (2012). 


   Back to top

  • Blum JS, Weller C, Booth CJ, Babar IA, Liang X, Slack FJ, and Saltzman WM. Topical treatment of K-ras and Pten mediated intravaginal cancer with camptothecin-loaded nanoparticles, Drug Delivery and Translational Research 1:383-394 (2011). 
  • Liu J, Jiang Z, Zhang SM, Liu C, Gross RA, Kyriakides TR, and Saltzman WM. Biodegradation, biocompatibility, and drug delivery in poly(omega-pentadecalactone-co-p-dioxanone) copolyesters, Biomaterials 32: 6646-6654 (2011).
  • McNeer Nicole Ali, Schleifman EB, Glazer PM, Saltzman WM. Polymer delivery systems for site-specific genome editing. J Control Release. 2011 May 18. [Epub ahead of print]
  • Hibino N, Villalona G, Pietris N, Duncan DR, Schoffner A, Roh JD, Yi T, Dobrucki W, Mejias D, Sawh-Martinez R., Harrington J, Sinusas A, Krause DS, Kyriakides T, Saltzman WM, Pober JS, Shin’oka T, and Breuer CK. Tissue engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel, FASEB Journal, published ahead of print May 12, 2011, doi:10.1096/fj.11-182246.
  • Cheng CJ and Saltzman WM. Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides, Biomaterials 32:6194-6203 (2011). [PMCID: in process]
  • Park J, Mattessich T, Jay SM, Agawu A, Saltzman WM, and Fahmy TM. Enhancement of surface ligand display on PLGA nanoparticles with amphiphilic ligand conjugates. Journal of Controlled Release, in press.
  • Sawyer AJ, Saucier-Sawyer J, Booth C, Liu J, Patel T, Piepmeier JM, and Saltzman WM. Convection-enhanced delivery of camptothecin-loaded polymer nanoparticles for treatment of intracranial tumors, Drug Delivery and Translational Research 1:34-42 (2011). [PMCID: in process]
  • Liu J, Jiang Z, Zhou J, Zhang S, and Saltzman WM. Enzymatic synthesized poly(amine-co-esters) as non-viral vectors for gene delivery, Journal of Biomedical Materials Research A 96A:456-465 (2011). PMCID: PMC3080021
  • McNeer, NA, Chin JY, Schleifman EB, Fields RJ, Glazer PM, and Saltzman WM. Nanoparticles deliver triplex-forming PNA for site-specific genomic recombination in CD34+ human hematopoietic progenitors. Molecular Therapy 19:172-180 (2011). PMCID: PMC3017438
  • Prasad S, Cody V, Saucier-Sawyer JK, Saltzman WM, Sasaki CT, Edelson RL, Birchall MA, Hanlon DJ. Polymer nanoparticles containing tumor lysates as antigen delivery vehicles for dendritic cell-based anti-tumor immunotherapy. Nanomedicine 7:1-10 (2011). PMCID: PMC3073408

2010                                                                                                                           Back to top

  • Kuo-Haller P, Cu Y, Blum J, Appleton JA, and Saltzman WM. Vaccine delivery by polymeric vehicles in the mouse reproductive tract induce sustained local and systemic immunity, Molecular Pharmaceutics 7:1585-1595 (2010). PMCID: PMC3004023
  • Roh JD, Sawh-Martinez R, Brennan MP, Jay SM, Devine L, Rao DA, Yi T, Mirensky TL, Nalbandian A, Udelsman B, Hibino N, Shinoka T, Saltzman WM, Snyder E, Kyriakides TR, Pober JS, Breuer CK. Tissue-engineered vascular grafts transform into mature blood vessel via an inflammation-mediated process of vascular remodeling. Proceedings of the National Academy of Sciences, 107:4669-74 (2010). PMCID: PMC2842056
  • Rubin J, Paltiel AD, and Saltzman WM. Are we studying what matters? Health priorities and NIH-funded biomedical engineering research. Annals of Biomedical Engineering 38:2237-2251 (2010). PMID: 20225125 [PMCID: in process]
  • Lo CT, Van Tassel PR, and Saltzman WM. Poly(lactide-co-glycolide) nanoparticle assembly for highly efficient delivery of potent therapeutic agents from medical devices, Biomaterials 31: 3631-3642 (2010). PMCID: PMC2837119
  • Jay SM, Shepherd BR, Andrejecsk JW, Kyriakides TR, Pober JS, and Saltzman WM. Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization, Biomaterials 31:3054-3062 (2010). PMCID: PMC2827647
  • Sirianni RW, Olausson P, Chiu AS, Taylor JR, and Saltzman WM. The behavioral and biochemical effects of BDNF containing polymers implanted in the hippocampus of rats.  Brain Research 1321:40-50 (2010). PMCID: PMC2834850
  • Sirianni R, Jang EH, Miller KM, and Saltzman WM. Parameter estimation methodology in a model of hydrophobic drug release from a polymer coating, Journal of Controlled Release 142:474-482 (2010). PMID: 19958804
  • Cartiera MS, Ferreira EC, Caputa C, Egan ME, Caplan MJ, and Saltzman WM. Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin, Molecular Pharmaceutics 7: 86-93 (2010). PMCID: PMC2815009
  • Cu Y, Lemoellic C, Caplan MJ, and Saltzman WM. Ligand-modified gene carriers increase uptake in target cells but reduce DNA release and transfection efficiency, Nanomedicine 6:334-343 (2010). PMCID: PMC2847641

2009                                                                                                                               Back to top

  • Liu J, Jiang Z, Zhang S, and Saltzman WM. Poly(ω-pentadecalactone-co-butylene-co-succinate) nanoparticles as biodegradable carriers for camptothecin delivery, Biomaterials 30:5707-5719 (2009). PMCID: PMC2774808
  • Lo CT, Van Tassel PR, and Saltzman WM. Simultaneous Release of Multiple Compounds from Mixed Nanoparticles Adsorbed to the Surface of an Implantable Medical Device, Biomaterials 30:4889-4897 (2009). PMCID: PMC2742909
  • Demento SL, Eisenbart SC, Foellmer HG, Platt C, Caplan MJ, Saltzman WM, Mellman I, Ledizet M, Fikrig E, Flavell RA, and Fahmy TM. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy, Vaccine 27:3013-3021 (2009). PMCID: PMC2695996
  • Bennewitz M and Saltzman WM. Nanotechnology for delivery of drugs to the brain for epilepsy, Neurotherapeutics 6(2):323-336 (2009). PMCID: PMC2673491
  • Woodrow KA, Cu Y, Booth CJ, Saucier-Sawyer J, Wood MJ, and Saltzman WM. Intravaginal gene silencing using biodegradable nanoparticles densely loaded with small-interfering RNA, Nature Materials 8:526-533 (2009). PMCID: PMC2693358
  • Park J, Fong PM, Lu J, Booth CJ, Russell KS, Saltzman WM, Fahmy TM. PEGylated PLGA nanoparticles for controlled delivery of doxorubicin,  Nanomedicine 5:410-418 (2009). PMCID: PMC2789916
  • Cartiera MS, Johnson KM, Rajendran V, Caplan MJ, and Saltzman WM. The uptake and intracellular fate of PLGA nanoparticles in epithelial cells, Biomaterials 30:2790-2798 (2009). PMID: 19232712 [PMCID: in process]
  • Cu Y and Saltzman WM. Mathematical modeling of molecular diffusion through mucus Advanced Drug Delivery Reviews, 61:101-114 (2009). PMCID: PMC2646819
  • Jay SM and Saltzman WM. Controlled Delivery of VEGF Via Modulation of Alginate Microparticle Ionic Crosslinking. Journal of Controlled Release 134:26-34 (2009). PMCID: PMC2678414
  • Woodrow  KA, Wood MJ, Saucier-Sawyer JK, Solbrig C, and Saltzman WM. Biodegradable meshes printed with extracellular matrix proteins support micropatterned hepatocyte cultures, Tissue Engineering 15:1169-79 (2009). PMCID: PMC2792091
  • Shepherd BR, SM Jay, WM Saltzman, G Tellides, and JS Pober, Human aortic smooth muscle cells promote arteriole formation by co-engrafted endothelial cells, Tissue Engineering 15:165-173 (2009). PMCID: PMC2679183
  • Cu Y and Saltzman WM. Controlled surface modification with poly(ethylene glycol) enhances diffusion of PLGA nanoparticles in human cervical mucus. Molecular Pharmaceutics 6:173-181 (2009). PMCID: PMC2637413

2008                                                                                                                                 Back to top

  • Sirianni R, Kremer J, Chen Y-L, Keeley F,and Saltzman WM. Local delivery of paclitaxel to heterogeneous tissue: the impact of extracellular matrix components. Biomacromolecules 9:2792-2798 (2008). PMID: 18785771
  • Nelson GN, Roh JD, Mirensky TL, Wang Y, Yi T, Tellides G, Pober JS, Shkarin P, Shapiro EM, Saltzman WM, Papademetris X, Fahmy TM, and Breuer CK. Initial evaluation of the use of USPIO cell labeling and noninvasive MR monitoring of human tissue-engineered vascular grafts in vivo. FASEB Journal 22:3888-3895 (2008). PMCID: PMC2574029
  • Wittmer CR, Phelps JA, Lepus CM, Saltzman WM, Harding MJ, Van Tassel PR. Multilayer nanofilms as substrates for hepatocellular applications, Biomaterials 29:4082-4090 (2008). PMCID: PMC2637394
  • Kobsa S and Saltzman WM. Bioengineering approaches to controlled protein delivery, Pediatric Research 63:513-519 (2008). PMID: 18427296
  • Fahmy TM, Demento SL, Caplan M, Mellman I, and Saltzman WM. Design opportunities and challenges for nanoparticle vaccines, Nanomedicine 3:343-355 (2008). PMID: 18510429
  • Jay SM, BR Shepherd, JP Bertram, JS Pober, and WM Saltzman, Engineering of multifunctional gels integrating highly efficient growth factor delivery with endothelial cell transplantation, FASEB Journal 22:2949-2956 (2008). PMCID: PMC2493461
  • Blum JS and Saltzman WM. High Loading Efficiency and Tunable Release of Plasmid DNA Encapsulated in Submicron Particles Fabricated from PLGA Conjugated with Poly-L-lysine,  Journal of Controlled Release 129:66-72 (2008). PMCID: PMC2494593
  • Roh JD, Nelson GN, Brennan MP, Mirensky TL, Yi T, Hazlet TF, Tellides G, Sinusas AJ, Pober JS, Saltzman WM, Kyriakides TR, Breuer CK.  Small –diameter biodegradable scaffolds for functional vascular tissue engineering in the mouse model.  Biomaterials. 29(10):1454-63 (2008). PMCID: PMC2375856
  • Zhang Q, Cuartas E, Mehta N, Gilligan J, Ke D, Saltzman WM, Kotas M, Ma M, Rajan S, and Vignery A. Replacement of bone marrow by bone in rat femurs: the bone bioreactor. Tissue Engineering 14:237-246 (2008). PMID: 18333776

2007                                                                                                                              Back to top

  • Haverstick K, Fleming A, and Saltzman WM.  Conjugation to Increase the Treatment Volume during Local Therapy: A Case Study with PEGylated Camptothecin, Bioconjugate Chemistry 18: 2115-2121 (2007).
  • Roh JD, Brenan MP, Udelsman BV, Lockhart B, Fong PM, Lopez-Soler RI, Saltzman WM, and Breuer CK. Centrifugal seeding increases seeding efficiency, cellular distribution, and collagen production of bone marrow stromal cells in porous biodegradable scaffolds. Tissue Engineering 13:2743-9 (2007). PMID: 17880269
  • Fong PM, Goyal A, Brennan MP, Park J, Moss RL, Saltzman WM, Breuer CK. Development of PTH eluting microspheres for the treatment of hypoparathyroidism. Journal of Surgical Research 143:195-197 (2007). PMID: 17720197
  • Neeves KB, Sawyer A, Foley CP, Saltzman WM, and Olbricht WL. Dilation and degradation of the brain extracellular matrix enhance penetration of infused polymer nanoparticles, Brain Research 1180:121-132 (2007). PMCID: PMC2169304
  • Saltzman WM and Kyriakides. Cell interactions with polymers In Textbook of Tissue Engineering, 3rd edition, RP Lanza, R Langer, J Vacanti (Ed.), Academic Press, NY, p. 279-292 (2007).
  • Fahmy TM, Fong PM, Park J, Constable T, Saltzman WM. Nanosystems for simultaneous imaging and drug delivery to T cells, The AAPS Journal 9:E171-E180 (2007). PMCID: PMC2751406
  • Sawyer AJ, Piepmeier JM, Saltzman WM. New methods for direct delivery of chemotherapy for treating brain tumors. Yale J Biol Med 79: 141-152 (2007). PMCID: PMC1994797
  • Ying V, Haverstick K, Page RL, Saltzman WM. Efficacy of camptothecin and polymer-conjugated camptothecin in tumor spheroids and implanted tumors, Journal of Biomaterials Science 18:1283-1299 (2007). PMID: 17939886
  • Fahmy TM, Schneck J, and Saltzman WM. A nanoscopic multivalent T cell antigen-presenting carrier: An approach for sensitive detection and drug delivery, Nanomedicine 3:75-85 (2007). PMID: 17379171
  • Solbrig CM, Saucier-Sawyer JK, Cody V, Saltzman WM, and Hanlon DJ. Polymer microparticles for immunotherapy from encapsulated tumor-associated antigens and whole tumor cells, Molecular Pharmaceutics 4: 47-57 (2007). PMID: 17217312
  • Wittmer CR, Phelps JA, Saltzman WM, and Van Tassel PR. Fibronectin terminated multilayer films: protein adsorption and cell attachment studies Biomaterials 28 (5):851-860 (2007). PMCID: PMC1773012

2006                                                                                                                              Back to top

  • Li H., Tran VV, Hu Y, Saltzman WM, Barnstable CJ, and Tombrin-Tink J. A PEDF peptide encapsulated in controlled release poly(lactide-co-glycolide) microspheres protects retinal ganglion cells from transient ischemic injury, Experimental Eye Research 83 (4): 824-833 (2006).
  • Keegan ME, Royce SM, Fahmy T, and Saltzman WM.  In vitro evaluation of biodegradable microspheres with surface-bound ligands, Journal of Controlled Release 110: 574-580 (2006). PMID: 16386325
  • Neeves KB, Lo CT, Foley CP, Saltzman WM, and Olbricht WL. Fabrication and characterization of microfluidic probes for convection enhanced drug delivery. Journal of Controlled Release 111:252-262 (2006). PMID: 16476500
  • Shen H, Hu YY, and Saltzman WM. DNA Diffusion in Mucus: effect of size, topology and charge of DNAs, Biophysical Journal 91:639-644 (2006). PMCID: PMC1483105
  • Mahoney M, Krewson C, Miller J, Saltzman WM. Impact of cell type and density on NGF distribution and bioactivity in three-dimensional collagen gel cultures. Tissue Engineering 12:1915-1927 (2006). PMID: 16889521
  • Saltzman M and Desai T. Drug delivery in the BME curricula. Annals of Biomedical Engineering 34:270-275 (2006).
  • Goyal A, Wang Y, Su H, Dobrucki LW, Brennan M, Fong P, Dardik A, Tellides G, Sinuses A, Pober J, Saltzman WM, Breuer CK. Development of a Model System for Preliminary Evaluation of Tissue Engineered Vascular Conduits. Journal of Pediatric Surgery 41:787-791 (2006). PMID: 16567194
  • Sheardown H and Saltzman WM.  Novel drug delivery systems for posterior segment ocular disease, in Ocular Angiogenesis, Barnstable C and Tombrin-Tink J (Ed.), 393-408 (2006).
  • Keegan ME and Saltzman WM. Surface modified biodegradable microspheres for DNA vaccine delivery, in DNA Vaccines, Saltzman, Brandsma, Shen (Ed), (2006). Also Methods in Molecular Medicine 127:107-113 (2006). PMID: 16988450

2005                                                                                                                           Back to top

  • Shen H, Ackerman AL, Cody V, Cresswell P, Edelson RL, Saltzman WM, and Hanlon DJ. Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles, Immunology 117:78-88 (2005). PMCID: PMC1782199
  • Anthony T, Fong P, Goyal A, Saltzman WM, Moss RL, and Breuer C.  Parathyroid hormone controlled release systems for surgical treatment for hypoparathyroidism, Journal of Pediatric Surgery, 40: 81-85 (2005). PMID: 15868563
  • Fahmy TM, Fong PM, Goyal A, and Saltzman WM. Targeted nanoparticles for drug delivery, Materials Today (Nano Today) 8:18-26 (2005).
  • Sanclimens G, Shen H, Giralt E, Albericio F, Saltzman WM, and Royo M.  Synthesis and screening of a small library of proline based biodendrimers for use as delivery agents, Peptide Science 80:800-814 (2005).
  • Gemeinhart RA, Luo D, and Saltzman WM. Cellular fate of a modular DNA delivery system mediated by silica nanoparticles, Biotechnology Progress 21:532-537 (2005). PMID: 15801794
  • Fahmy TM, Samstein RM, Harness C, and Saltzman WM.  Sustained target presentation in biodegradable polymers by surface modification with fatty acid conjugates, Biomaterials 26: 5727-36 (2005).
  • Tan J, Gemeinhart RA, Ma M, and Saltzman WM. Improved cell adhesion and proliferation on synthetic phosphonic acid-containing hydrogels, Biomaterials, 26: 3663-3671 (2005). PMID: 15621257
  • Mahoney MJ, Chen R, Tan J, and Saltzman WM. Biomaterials with microchannels influence neurite growth and architecture.  Biomaterials 26: 771–778 (2005). PMID: 15350782

2004                                                                                                                                                                                       Back to top

  • Fleming AB, Haverstick KL, and Saltzman WM. In vitro cytotoxicity and in vivo distribution after direct delivery to the rat brain of PEG-camptothecin conjugates.  Bioconjugate Chemistry 15:1364-1375 (2004). PMID: 15546204
  • Keegan ME, Falcone JL, Leung T, and Saltzman WM.  Biodegradable microspheres with enhanced capacity for covalently bound surface ligands, Macromolecules 37: 9779-9784 (2004).
  • Shen H, Tan J, and Saltzman WM. Surface-mediated gene transfer from nanocomposites of controlled texture, Nature Materials, 3: 569-574 (2004). PMID: 15258575
  • Stroh M, Williams R, Zipfel W, Ma S, Webb WW, and Saltzman WM. Multiphoton microscopy guides neurotrophin modification with poly(ethylene glycol) to enhance interstitial diffusion, Nature Materials 3: 489-494  (2004).
  • Willits RK and Saltzman WM. The effect of synthetic polymers on the migration of monocytes through human cervical mucus. Biomaterials 25, 4563-4571 (2004).
  • Luo D, Han E, Belcheva N, and Saltzman WM. A self-assembled, modular DNA delivery system mediated by silica nanoparticles, Journal of Controlled Release 95: 333-341 (2004).
  • Tan J and Saltzman WM. Biomaterials with hierarchically defined micro- and nano-scale structure.  Biomaterials 25: 3593-3601  (2004).
  • Qian L and Saltzman WM.  Improving the expansion and neuronal differentiation of mesenchymal stem cells through culture surface modification.  Biomaterials 25:1331-1337 (2004).

2003                                                                                                                            Back to top

  • Saltzman WM.  Cost-reducing protein production and delivery methods for sexually transmitted disease prevention. IEEE Engineering in Medicine and Biology Magazine 22:43-48 (2003).
  • Shain W, Spartaro L, Dilgen J, Haverstick K, Retterer S, Isaacson M, Saltzman M, and Turner JN.  Controlling cellular reactive responses around neural prosthetic dvices using peripheral and local intervention strategies.  IEEE Transactions on Neural Systems and Rehabilitation Engineering 11:186-188 (2003).
  • Keegan ME, Whittum-Hudson JA, and Saltzman WM.  Biomimetic design in microparticulate vaccines.  Biomaterials 24:4435-4443 (2003).
  • Chiellini F, Bizzari R, Ober CK, Schmalijohann D, Yu T, Saltzman WM, Solaro R, Chiellini E.  Surface patterning and biological evaluation of semi-interpenetrated poly(HEMA)/poly(alkyl beta-malolactonate)s. Macromol. Symp. 197: 369—379 (2003).
  • Bizzari R, Chiellini F, Ober CK, Saltzman WM, Solaro R, and Chiellini E. Malolactonate polymers and copolymers for biomedical applications. Macromol. Symp. 197: 303-314 (2003).
  • Stroh M, Zipfel W, Williams RM, Webb WW, and Saltzman WM. Diffusion of nerve growth factor in rat striatum as determined by multiphoton microscopy, Biophysical Journal, 85:581-588 (2003).
  • Cypes SH, Saltzman WM, Giannelis EP.  Organosilicate-polymer drug delivery systems: controlled release and enhanced mechanical properties, Journal of Controlled Release 90:163-169 (2003).
  • Shen H, Goldberg E, and Saltzman WM.  Gene expression and mucosal immune responses after vaginal DNA immunization in mice using a controlled delivery matrix, Journal of Controlled Release 86:339-348 (2003).

2002                                                                                                Back to top

  • Bizzarri R, Chiellini F, Ober CK, Saltzman WM, and Solaro R.  Influence of structural parameters on the ring-opening polymerization of new alkyl malolactonate monomers and on the biocompatibility of polymers therefrom, Macromol. Chem. Phys. 203:1684-1693  (2002).
  • Tan J and Saltzman WM.  Topographical control of human neutrophil motility on micropatterned materials with various surface chemistry, Biomaterials, 23: 3215-3225 (2002).            
  • Saltzman WM and Olbricht WL.  Building drug delivery into tissue engineering.  Nature Reviews Drug Discovery 1:177-186 (2002).
  • Fleming AB and Saltzman WM.  Pharmacokinetics of the carmustine implant, Clinical Pharmacokinetics 41:403-419 (2002).
  • Luo D, Haverstick K, Belcheva N, Han E, and Saltzman WM.  Poly(ethylene glycol)-conjugated dendrimer for biocompatible, high efficient, and low cost DNA delivery, Macromolecules 35:3456-3462 (2002).

2001                                                                                                                                 Back to top

  • Mahoney MJ and Saltzman WM.  Transplantation of brain cells assembled around a programmable, synthetic microenvironment.  Nature Biotechnology 19:934-938 (2001).
  • Tan J, Shen H, and Saltzman WM. Micron-scale positioning of features influences the rate of polymorphonuclear leukocyte migration.  Biophysical Journal 81:2569-2579 (2001).
  • Whittum-Hudson JA, Rudy D, Gerard H, Vora G, Davis E, Haller PK, Prattis SM, Hudson AP, Saltzman WM, and Stuart ES. The anti-idiotypic antibody to chlamydial glycolipid exoantigen (GLXA) protects mice against genital infection with a human biovar of Chlamydia trachomatis.  Vaccine 19: 4061-71 (2001).
  • Baldwin SP and Saltzman WM.  Aggregation enhances catecholamine synthesis in cultured cells, Tissue Engineering 7:179-190 (2001).
  • Willits RK and Saltzman WM. Synthetic polymers alter the structure of cervical mucus, Biomaterials 22:445-452 (2001).
  • Fleming AB and Saltzman WM. Spatially-separated, simultaneous delivery of a protein and protein antagonist can produce sharp boundaries of drug activity, Journal of Controlled Release 70:29-36 (2001).

2000                                                                                                       Back to top

  • Saltzman WM. Cell interactions with polymers In Textbook of Tissue Engineering, 2nd edition, RP Lanza, R Langer, J Vacanti (Ed.), Academic Press, NY, p. 221-235 (2000).
  • Luo D and Saltzman WM. Enhancement of transfection by physical concentration of DNA at the cell surface, Nature Biotechnology, 18: 893-895 (2000).
  • Tan J, Shen H, Carter KL and Saltzman WM.  Controlling human polymorphonuclear leukocyte motility using microfabrication technology, Journal of Biomedical Materials Research 51: 694-702 (2000).
  • Saltzman WM, Sherwood JK, Adams DR, Castle P, and Haller P. Long-term vaginal antibody delivery: delivery systems and biodistribution, Biotechnology and Bioengineering, 67: 253-264 (2000).
  • Saltzman WM and Mahoney MJ.  Cell structure and motion: a) extracellular matrix and cell adhesion.  in Encyclopedia of Animal and Plant Cell Technology, Spier R (Ed.), Wiley, New York,  p. 481 to 495 (2000).
  • Saltzman WM.  Interstitial transport in the brain: principles for local drug delivery.  Handbook of Biomedical Engineering, Bronzino JD (Ed.), CRC Press, 2nd Edition, p. 99-1 to 99-14 (2000).
  • Luo D and Saltzman WM.  Review: Synthetic DNA delivery systems, Nature Biotechnology 18:33-39 (2000).

Before 2000                                                                                                         Back to top

  • Luo D, Woodrow-Mumford K, Belcheva N, and Saltzman WM.  Controlled DNA delivery systems, Pharmaceutical Research 16:1300-1308 (1999).
  • Saltzman WM.  Delivering tissue regeneration [commentary], Nature Biotechnology 17:534-535 (1999).
  • Mahoney MJ and Saltzman WM.  Millimeter-scale positioning of a NGF source and biological activity, Proceedings of the National Academy of Sciences 96:4536-4539 (1999).
  • Tan J and Saltzman WM. Influence of synthetic polymers on neutrophil migration in three-dimensional collagen gels, Journal of Biomedical Materials Research 46:465-474 (1999).
  • Belcheva N, Woodrow-Mumford K, Mahoney MJ, and Saltzman WM.  Synthesis and characterization of polyethylene glycol-mouse nerve growth factor conjugates. Bioconjugate Chemistry, 10: 932-937 (1999).
  • Saltzman WM, Mak MW, Mahoney MJ, Duenas ET, and Cleland JL.  Intracranial delivery of recombinant nerve growth factor: release kinetics and protein distribution for three delivery systems.  Pharmaceutical Research 16:232-240 (1999).
  • Saltzman WM, Livingston TL, and Parkhurst MR. Antibodies to CD18 influence the migration of neutrophils through collagen gels.  Journal of Leukocyte Biology: 65:356-363 (1999).
  • Mahoney MJ and Saltzman WM. Cultures of cells from fetal rat brain: methods to control composition, morphology, and biochemical activity. Biotechnology and Bioengineering: 62:461-467 (1999).
  • Haller MF and Saltzman WM.  Localized delivery of proteins in the brain: Can transport be customized? Pharmaceutical Research 15:377-385 (1998).
  • Baldwin SP and Saltzman WM.  Materials for protein delivery in tissue engineering, Advanced Drug Delivery Reviews 33:71-86 (1998).
  • Fung LK, Ewend M, Sills A, Sipos EP, Thompson R, Watts M, Colvin OM, Brem H, and Saltzman WM.  Pharmacokinetics of interstitial delivery of carmustine, 4-hydroperoxycyclophosphamide and paclitaxel from a biodegradable polymer implant in the monkey brain. Cancer Research 58:672-684 (1998).
  • Kuo PY, Sherwood JK, and Saltzman WM.  Topical antibody delivery systems produce sustained levels in mucosal tissue and blood.  Nature Biotechnology 16:163-167 (1998).
  • Belcheva N, Baldwin S, and Saltzman WM.  Synthesis and characterization of polymer-(multi)-peptide conjugates for control of specific cell aggregation, Journal of Biomaterials Science-Polymer Edition 9:207-226 (1998).
  • Haller MF and Saltzman WM.  Growth factor delivery systems, Journal of Controlled Release 53:1-6 (1998).
  • Wyatt TL, Whaley KJ, Cone RA, and Saltzman WM. Antigen-releasing polymer rings and microspheres stimulate mucosal immunity in the vagina, Journal of Controlled Release 50:93-102 (1998).
  • Saltzman WM.  Weaving cartilage at zero G: the reality of tissue engineering in space [commentary]. Proceedings of the National Academy of Sciences, 94:13380-13382 (1997).
  • Kuntz RM and Saltzman WM.  Polymeric controlled delivery for immunization, Trends in Biotechnology 15:364-369 (1997).
  • Fung LK and Saltzman WM. Polymeric implants for cancer chemotherapy, Advanced Drug Delivery Reviews 26:209-230 (1997).
  • Kuntz R and Saltzman WM. Neutrophil motility in extracellular matrix gels: mesh size and adhesion affect speed of migration, Biophysical Journal 72:1472-1480 (1997).
  • Wyatt TL and Saltzman WM.  Protein delivery from non-degradable polymer matrices in Protein Delivery-Physical Systems, Saunders L and Hendren W (Ed.), Plenum Press, New York, p. 119-137 (1997).
  • Saltzman WM.  Growth factor delivery in tissue engineering.  MRS Bulletin 21:62-65 (1996).
  • Krewson CE and Saltzman WM. Nerve growth factor delivery and cell aggregation enhance choline acetyltransferase activity after neural transplantation.  Tissue Engineering 2:183-196 (1996).
  • Mahoney MJ and Saltzman WM, Controlled release of proteins to tissue transplants for the treatment of neurodegenerative disorders, Journal of Pharmaceutical Science 85:1276-1281 (1996).
  • Whittum-Hudson JA, Prendergast RA, Saltzman WM, An LL, and MacDonald AB.  Oral immunization with an anti-idiotypic antibody to the exolipid antigen protects against experimental Chlamydia trachomatis infection, Nature Medicine 2:1116-1122 (1996).
  • Krewson CE and Saltzman WM.  Transport and elimination of recombinant human NGF during long-term delivery to the brain. Brain Research 727:169-181 (1996).
  • Parkhurst MR and Saltzman WM.  Controlled delivery of antibodies against leukocyte adhesion molecules from polymer matrices, Journal of Controlled Release 42:273-288 (1996).
  • Baldwin SP, Krewson CE, and Saltzman WM.  PC12 cell aggregation and neurite growth in gels of collagen, laminin, and fibronectin, International Journal of Developmental Neuroscience 14:351-364 (1996).
  • Krewson CE, Dause RB, Mak M, and Saltzman WM.  Stabilization of nerve growth factor in controlled-release polymers and in tissues, Journal of Biomaterials Science  8:103-117 (1996).
  • Baldwin SP and Saltzman WM, Polymers for tissue engineering. Trends in Polymer Science 4:177-182 (1996).
  • Kuo PYP and Saltzman WM.  Novel systems for controlled delivery of macromolecules, Critical Reviews in Eukaryotic Gene Expression 6:59-73 (1996).
  • Fung LK, Shin M, Tyler B, Brem H, and Saltzman WM.  Chemotherapeutic drugs released from polymers: Distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea in the rat brain, Pharmaceutical Research 13:671-682 (1996).
  • Dai W and Saltzman WM.  Fibroblast aggregation by suspension with conjugates of poly(ethylene glycol) and RGD, Biotechnology and Bioengineering 50:349-356 (1996).
  • Sherwood JK, Zeitlin L, Cone RA, and Saltzman WM.  Controlled release of antibodies for sustained topical passive immunoprotection of female mice against genital herpes.  Nature Biotechnology 14:468-471 (1996).
  • Saltzman WM. Cell interactions with polymers In Textbook of Tissue Engineering, RP Lanza, WL Chick, and R Langer (Ed.), Springer, NY, p. 227-248 (1996).
  • Sherwood JK, Zeitlin L, Chen X, Whaley KJ, Cone RA, and Saltzman WM.  Residence half time of IgG administered topically to the mouse vagina, Biology of Reproduction 54:264-269 (1996).
  • Mak M, Fung L, Strasser JF, and Saltzman WM.  Distribution of drugs following controlled delivery to the brain interstitium, Journal of Neuro-Oncology 26:91-102 (1995).
  • Strasser JF, Fung L, Eller S, Grossman SA, and Saltzman WM.  Distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in the rabbit brain following interstitial delivery by biodegradable polymer implants, Journal of Pharmacology and Experimental Therapeutics 275:1647-1655 (1995).
  • Krewson CE and Saltzman WM.  Targeting of peptides and proteins in the brain following release from implantable polymers in  Trends and Future Perspectives in Peptide and Protein Drug Delivery, VHL Lee, M Hasida, and Y Mizushima (Ed.), Harland Academic Publishers, London, p. 273-294 (1995).
  • Krewson CE, Klarman M, and Saltzman WM.  Distribution of nerve growth factor following direct delivery to brain interstitium, Brain Research 680:196-206 (1995).
  • Saltzman WM, Radomsky ML, Whaley KJ, and Cone RA.  Antibody diffusion in human cervical mucus, Biophysical Journal 66:508-515 (1994).
  • Gutsche AT, Parsons-Wingerter P, Chand D, Saltzman WM, and Leong KW.  N-acetylglucosamine and adenosine derivatized surfaces for cell culture: 3T3 fibroblast and chicken hepatocyte response, Biotechnology and Bioengineering 43:801-809 (1994).
  • Krewson CE, Chung SW, Dai W, and Saltzman WM.  Cell aggregation and neurite growth in gels of extracellular matrix molecules, Biotechnology and Bioengineering 43:555-562 (1994).
  • Dang W, Colvin OM, Brem H, and Saltzman WM.  Covalent coupling of methotrexate to dextran enhances the penetration of cytotoxicity into a tissue-like matrix, Cancer Research 54:1729-1735 (1994).
  • Parkhurst MR and Saltzman WM, Leukocytes migrate in three-dimensional gels of midcycle cervical mucus, Cellular Immunology 156:77-94 (1994).
  • Dang W and Saltzman WM.  Controlled release of macromolecules from a biodegradable polyanhydride matrix, Journal of Biomaterials Science  6:297-311 (1994).
  • Salehi-Had S and Saltzman WM.  Controlled intracranial delivery of antibodies  in the rat in Protein Formulations and Delivery, J. Cleland and R. Langer (Ed.), ACS Symposium Series 567:278-291 (1994).
  • Dai W, Belt J, and Saltzman WM.  Cell-binding peptides conjugated to poly(ethylene glycol) promote neural cell aggregation, Bio/Technology 12:797-801 (1994).
  • Beaty CE and Saltzman WM. Controlled growth factor delivery induces differential neurite outgrowth in three-dimensional cell cultures.  Journal of Controlled Release 24:15-23 (1993).
  • Saltzman WM, Sheppard NF, McHugh MA, Dause R, Pratt JA, Dodrill AM.  Controlled antibody release from a matrix of poly(ethylene-co-vinyl acetate) fractionated with a supercritical fluid. Journal of Applied Polymer Science 48:1493-1500 (1993).
  • Saltzman WM.  Antibodies for treating and preventing disease: the potential role of polymeric controlled release. Critical Reviews in Therapeutic Drug Carrier Systems 10:111-142 (1993).
  • Parsons-Wingerter P and Saltzman WM. Growth versus function in three-dimensional culture of single and aggregated hepatocytes within collagen gels.  Biotechnology Progress 9:600-607 (1993).
  • Saltzman WM, Parkhurst MR, Parsons-Wingerter P, and Zhu W.-H.  Three-dimensional cell cultures mimic tissues. Annals of the New York Academy of Sciences 665:259-273 (1992).
  • Parkhurst MR and Saltzman WM.  Quantification of human neutrophil motility in three-dimensional collagen gels: effect of collagen concentration.  Biophysical Journal 61:306-315 (1992).
  • Radomsky ML, Whaley KJ, Cone RA, and Saltzman WM.  Controlled vaginal delivery of antibodies in the mouse, Biology of Reproduction 47:133-140 (1992).
  • Dang W and Saltzman WM. Dextran retention in the rat brain following release from a polymer implant.  Biotechnology Progress 8:527-532 (1992).
  • Sherwood JK, Dause R, and Saltzman WM. Controlled antibody delivery systems, Bio/Technology 10:1446-1449 (1992).
  • Saltzman WM, Parsons-Wingerter P, Leong KW, and Lin S, Fibroblast and hepatocyte behavior on synthetic polymer surfaces. Journal of Biomedical Materials Research 25:741-759 (1991).
  • Saltzman WM and Tena L.  Spermicide permeation through biocompatible polymers. Contraception 43:497-505 (1991).
  • Saltzman WM and Radomsky ML.  Molecules released from polymers: diffusion and elimination from brain tissue, Chemical Engineering Science 46:2429-2444 (1991).
  • Reinhard CS, Radomsky ML, Saltzman WM, Hilton J and Brem H.  Polymeric controlled release of dexamethasone in normal rat brain. Journal of Controlled Release 16:331-340 (1991).
  • Powell EM, Sobarzo MR, and Saltzman WM.  Controlled release of nerve growth factor from a polymeric implant, Brain Research 515:309-311 (1990).
  • Saltzman WM.  Transport in porous polymers, in Absorbent Polymer Technology, L. Brannon-Peppas and R.S. Harland (Eds.), Elsevier, Amsterdam, 171-199 (1990).
  • Radomsky ML, Whaley K, Cone RA, and Saltzman WM.  Macromolecules released from polymers: Diffusion into unstirred fluids. Biomaterials 11:619-624 (1990).
  • Zydney AL, Saltzman WM, and Colton CK. The hydraulic resistance of red cell beds in an unstirred filtration cell, Chemical Engineering Science 44:147-159 (1989).
  • Freese A, Sabel BA, Saltzman WM, During MJ, and Langer R. Controlled release of dopamine from a polymeric brain implant: in vitro characterization, Experimental Neurology 103:234-238 (1989).
  • Saltzman WM and Langer R. Transport rates of proteins in porous polymers with known microgeometry, Biophysical Journal 55:163-171 (1989).
  • During MJ, Sabel BA, Freese A, Saltzman WM, Deutz A, Roth RH, and Langer R.  Controlled release of dopamine from a polymeric brain implant: in vivo characterization, Annals of Neurology 25:351-356 (1989).
  • Mathiowitz E, Saltzman WM, Domb A, Dor P, and Langer R.  Polyanhydride microspheres as drug carriers. II. Microencapsulation by solvent removal, Journal of Applied Polymer Science  35:755-774 (1988).
  • Vacanti JP, Morse M, Domb A, Saltzman WM, Perez-Atayde A, and Langer R. Selective cell transplantation using bioabsorbable artificial polymers as matrices, Journal of Pediatric Surgery 23:3-9 (1988).
  • Mullon C, Saltzman WM, and Langer R. A new method for computer assisted visualization and analysis of the distribution of matrix-bound proteins, Bio/Technology 6:927-929 (1988).
  • Saltzman WM, Pasternak SH and Langer R.  Quantitative image analysis for developing microstructural descriptions of heterogeneous materials, Chemical Engineering Science 42: 1989-2001 (1987).
  • Saltzman WM, Pasternak SH, and Langer R.  Microstructural models for diffusive transport in porous polymers in Recent Advances in Controlled Release Technology, ACS Symposium Series 348, P.I. Lee and W.R. Good (Ed.), pp 17-31 (1987).

EDITED BOOKS                                                                                                Back to top

  • Saltzman WM, Brandsma J, and Shen H (Editors), DNA Vaccines, Methods in Molecular Medicine series, Humana Press (2006).
  • Luo D and Saltzman WM (Editors), Synthetic DNA Delivery Systems, Landes Publishing (2003).

Research Interests

Drug Delivery
Gene Therapy
Tissue Engineering


Department of Biomedical Engineering  |  Yale University
Malone Engineering Center (map)
55 Prospect St.  |  New Haven, CT 06511

Vascular Biology & Therapeutics Program | Yale School of Medicine
Amistad Research Building (map)
10 Amistad St.  |  New Haven, CT 06520

For Undergraduate Research Opportunities

Thank you for your interest in a research position in our lab! We have an application process to help match interested students with mentors and current research projects. Submission of applications are rolling, but we will review all applications on September 14th (fall term) and January 18th (spring and summer term). If you have any questions about the application, please contact We look forward to receiving your application.